Grapefruit juice postponed the tmax of diazepam from 1.50 h to 2.06 h (P < 0.01). The mean AUC(0-24) of diazepam was increased 3.2-fold (P < 0.001) and Cmax was increased 1.5-fold (P < 0.05) by the grapefruit juice. Grapefruit juice has been reported to markedly improve the bioavailability of triazolam, midazolam, terfenadine, cyclosporine and several dihydropyridine. Blood samples were collected for a 24 h period, and whole blood concentrations of diazepam were measured enzyme immunoassay. Oral (5 mg) diazepam was administered with either 250 ml water and grapefruit juice. You should also avoid alcohol if you are taking Xanax as they both have sedative effects which can result in a fatal overdose. Eight healthy male and female subjects participated in this study. But it’s not clear how risky the interaction between grapefruit and statins is. Statins that aren’t known to interact with grapefruit include rosuvastatin (Crestor), pravastatin, fluvastatin (Lescol XL), and pitavastatin (Livalo). The effect from grapefruit can last longer than 24 hours and some people are more sensitive. The statins most affected by grapefruit are atorvastatin (Lipitor), lovastatin, and simvastatin (Zocor). In this study, our aim was to investigate the effects of grapefruit juice on plasma concentrations of diazepam. Klonopin And Grapefruit This drug is often abused by teens List. Because these drugs are metabolized by the hepatic cytochrome P450 isozyme (CYP) 3A4, the inhibitory effect of grapefruit juice is thought to results from inhibition of CYP3A4. Grapefruit juice has been reported to markedly improve the bioavailability of triazolam, midazolam, terfenadine, cyclosporine and several dihydropyridine calcium channel blockers including felodipine, nifedipine, nitrendipine and nisoldipine. Also, Buy our other anti-anxiety products like Buy Klonopin, Buy Ativan, etc.
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